Restarted the game recently.
System Information: Intel Core i5-2500K 3.6 GHz, Windows 7 SP 1 (64 bit), Nvidia GTX 780 Ti, 16 GB RAM
Awesome settings, 1920*1080 resolution, everything maxed out. Experienced some stuttering coming out of The Hand That Feeds office.
It seems the game doesn't really distribute the load between the four CPU cores. The load on core 0 is somewhere around 80-90%, the other three are maxed around 40%.
GPU usage didn't go above 58%.
When I lowered the shadow distance to 12 meters stuttering almost vanished. Interesting.
Further testing indicates stuttering occures when the load suddenly goes up on the other three cores for a brief period. Or not. I give up.